Pittsburgh Ambulatory Assist Lung (PAAL) 

• Integrated pump-oxygenator for simplified respiratory assistance
  
  
• The unique fiber bundle design provides high oxygenation efficiencies (>276 ml/min/m2)
  
  
• The small simple design is intended for ambulatory support for 1-3 months
  
  
• Bench driven design that is computational fluid dynamics optimized

ULFED (Ultra-low-flow ECCO2R Device)

• Extracorporeal CO2 removal (ECCO2R) at hemodialysis blood flows (250 mL/min) to prevent intubation or allow protective ventilation for patients with COPD and ARDS
  
  
• Impeller mixing enhances gas exchange to remove 37% of the metabolic CO2 production
  
  
• Operation analogous to dialysis allows simplified and minimally invasive respiratory support

ULFED (Ultra-low-flow ECCO2R Device)

• Integrated ECCO2R device is compact and wearable, allowing for patient ambulation
  
  
• Blood flow rates below 1 L/min permit less invasive cannulation
  
  
• The device removes greater than 30% of metabolic CO2 and can prevent intubation or allow protective ventilation for patients with COPD and ARDS

Low Flow CO2 Removal
PRAL to Hemolung

• ALung is commercializing the Hemolung Respiratory Assist System (RAS), a dialysis-like alternative or supplement to mechanical ventilation originally developed at the University of Pittsburgh.
  
  
• The Hemolung RAS removes carbon dioxide and delivers oxygen directly to the blood, allowing the patient's lungs to rest and heal. A simple extracorporeal circuit, small venous catheter, and techniques similar to hemodialysis make the Hemolung RAS easy to use.

Acidic Sweep Gas

• A dilute acidic gas is introduced to the oxygen sweep gas passed through the hollow fiber membranes of artificial lung devices
  
  
• Dilute sulfur dioxide in oxygen sweep gas can further increase CO2 removal rates by creating an acidic microenvironment at the HFM surface facilitating dehydration of bicarbonate to CO2
  
  
• Dilute acidic sweep gas can increase CO2 removal, and when used in combination with bioactive CA-HFMs has a synergistic effect to increase CO2 removal efficiency by 150%

Oxygen Depletion Device (ODD)
Anaerobically Stored Red Blood Cells with Extended Shelf Life

• Develop a novel blood storage system that will extend the shelf life of additive system red cell units
  
  
• Deliver red cells of higher efficacy and lower toxicity for transfusion therapy
  
  
• Red cells are stored in a modified additive solution under oxygen-depleted condition (anaerobic storage).

Devices for Inflammatory System Modulation
Engineering of a Pheresis Intervention for Sepsis (SEPsIS) Hemoadsorption Device

• Extracorporeal blood purification device that removes the inflammatory molecules which cause severe sepsis
  
  
• Device packed with adsorbing polymer beads covered in biocompatible coating
  
  
• Cytokines involved in sepsis adsorbed on beads

White Cell Modulation

• Fiber device containing immobilized CXCL8 which will have the ability to alter the activity state of neutrophils in whole blood.
  
  
• Techniques being developed could eventually be applied to numerous diseases involving all circulating cells.

Biohybrid Artificial Lung

• Composed of microfabricated units that mimic exchange sacs of natural lungs
  
  
• Vascular cells coat blood pathways for improved blood biocompatibility
  
  
• Compact respiratory device design compared to traditional respiratory devices

Polymer, Fiber and Surface Modifications

• Fiber polymer coatings for improved blood biocompatibility
  
  
• Attachment of biomolecules on fibers to provide novel functionality
  
  
• Coatings of active polymeric microspheres on membrane surfaces